Registration Dossier
Registration Dossier
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EC number: 211-330-1 | CAS number: 638-29-9
Endpoint summary
Administrative data
Description of key information
Valeryl chloride was found to be highly corrosive to the rabbit skin under semiocclusive conditions. Dermal application for 3 minutes and 1 hour caused full thickness necrosis within 1 hour.
As valeryl chloride corrodes the skin, it can be expected to have a similar effect on the eyes also.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
Valeryl chloride was applied to the skin of one New Zealand White rabbit for 3 minutes and 1 hour under semiocclusive conditions in a GLP compliant OECD guideline 404 study (1997). Full thickness necrosis was observed at 1 and 24 hour after patch removal at both exposure durations and erythema and edema (scores of 2 and 3) were observed beyond the area of exposure. Therefore, the study was terminated after 24 hours. Valeryl chloride was judged highly corrosive to the skin.
Supportingly, in the in vitro skin corrosion test Corrositex (2011) the corrosive potential of valeryl chloride was also observed. The mean break through time of 9 min 30 sec indicates a rather intermediate corrosive potential resulting in classification as Skin Corr. 1B. But based on the in vivo results the more severe classification as Skin Corr. 1A is justified.
Eye irritation
In accordance with column 2 of REACH Annex VII, no testing on eye irritation is necessary as the substance is classified as corrosive to the skin according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (H314, Category 1A).
As valeryl chloride corrodes the skin, it can be expected to have a similar effect on the eyes also. Furthermore, structurally similar acid chlorides, e.g, butyryl chloride/CAS 141-75-3, isobutyryl chloride/79-30-1 and pivaloyl chloride/CAS 3282-30-2 cause serious damage to the eyes.
Justification for classification or non-classification
Based on the available data, valeryl chloride needs to be classified according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (Skin Corr. 1A, H314 and Eye Dam. 1, H318).
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