Dimethylammonium chloride

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Experimental determination according to national guideline, no information about GLP

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1980

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: AFNOR test, Norme Expérimentale N.F.T. 90-301 (1974)

Principles of method if other than guideline:

Definition of 24 h IC50 for Daphnia (immobilization concentration for 50 % of the animals at 24 h)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Dimethylamine

EC Number:

204-697-4

EC Name:

Dimethylamine

Cas Number:

124-40-3

IUPAC Name:

N-methylmethanamine

Details on test material:

dimethylamine was used as 40 % water solution.

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Test conditions

Hardness:

320 mg CaCO3/L

Test temperature:

15 °C

pH:

7.4

Dissolved oxygen:

more than 95 % saturation

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

IC50

Effect conc.:

48 mg/L

Nominal / measured:

not specified

Conc. based on:

act. ingr.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

IC50 (24h) = 48 mg/L for the substance Dimethylamine (CAS-No. 124-40-3, EC-No. 204-697-4); the test result is also applicable for Dimethylamine hydrochloride (CAS-No. 506-59-2, EC-No. 208-046-5), which is a near analogue.

Executive summary:

Calamari D. et.al. performed an experiment according to AFNOR, Norme Expérimentale N.F.T. 90-301 (1974) to test the acute toxicity of dimethylamine (and other amines) to aquatic invertebrate Daphnia magna in 1980. This test establishes the 24 h IC50 (immobilization concentration for 50 % of the animals at 24 h) in hard water (320 mg CaCO3/L). As result an IC50 (24h) of 48 mg/L is reported for Dimethylamine.

Hence, the substance Dimethylamine hydrochloride (CAS-No. 506-59-2, EC-No. 208-046-5), which is a near analogue to Dimethylamine (CAS-No. 124-40-3, EC-No. 204-697-4) should also have an IC50 of 48 mg/L.