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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP near guideline study available as unpublished report (in German) but otherwise fully adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
Nominal: 7, 31.6, 52.2, 78.3, 104.4 mg/L
Analysed: 6.08, 20.00, 23.98, 38.87, 61.80 mg/L
No. of animals per sex per dose:
10
Control animals:
no
Statistics:
Probit analysis based on Finney (1971)

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
28.1 mg/L air (analytical)
Exp. duration:
4 h
Remarks on result:
other: 5/20 mortalities at 23.98 and 18/20 mortalities at 38.87 mg/L
Sex:
male
Dose descriptor:
LC50
Effect level:
25.7 mg/L air (analytical)
Exp. duration:
4 h
Remarks on result:
other: 3/10 mortalities at 23.98 and 10/10 at 38.87 mg/L
Sex:
female
Dose descriptor:
LC50
Effect level:
30 mg/L air (analytical)
95% CL:
25.5 - 36.8
Exp. duration:
4 h
Remarks on result:
other: 2/10 mortalities at 23.98 and 8/10 mortalities at 38.87 mg/L
Mortality:
Mortality at 6.08, 20.00, 23.98, 38.87, 61.80 mg/L
Males: 0/10, 1/10, 3/10, 10/10, 10/10
Females: 0/10, 1/10, 2/10, 8/10, 10/10
Clinical signs:
other:

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acute inhalation LC50 > 20 mg/L
Executive summary:

Acute inhalation toxicity of toluene was investigated in 5 groups of 10 male and female rats exposed for 4 hours at concentrations of 6.08, 20.00, 23.98, 38.87 or 61.80 mg/L.

Adverse clinical signs and mortality were seen at concentrations of 20 mg/L and above. All surviving animals were normal by day 3. The LC50 exceeded 20 mg/L (25.7 mg/L in males, 30 mg/L in females).

Toluene does not warrant classification under GHS/CLP.