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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: repeated dose
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Environmental health control for the rubber industry, part II
Author:
McCormick, W.E.:
Year:
1972
Bibliographic source:
Rubber Chemistry and Technology 45, 627-637
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
other: repeated dose toxicity
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
EC Number:
204-327-1
EC Name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
Cas Number:
119-47-1
Molecular formula:
C23H32O2
IUPAC Name:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
Details on test material:
migrated data set

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Wesson oil
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
migrated data set
Frequency of treatment:
migrated data set
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw/d
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no signs of systemic toxicity, severe degrees of skin irritation

Applicant's summary and conclusion

Executive summary:

Repeated dose application on rabbit skins showed no signs of systemic toxicity, but severe degrees of skin irritation (McCormick 1972).