Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: repeated dose
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study data do not give sufficient experimental details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
other: repeated dose, inhalation
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
EC Number:
204-327-1
EC Name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
Cas Number:
119-47-1
Molecular formula:
C23H32O2
IUPAC Name:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
Details on test material:
no data

Test animals

Species:
other: rats, guinea pigs, dogs
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Duration of treatment / exposure:
60 exposures over a period of 84 d
Frequency of treatment:
no data
No. of animals per sex per dose:
no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No significant signs of toxicity were observed throughout the study.

Applicant's summary and conclusion

Executive summary:

Repeated dose inhalation study with animals, no signs of toxicity were observed (American Cyanamid Company 1959).