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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report date:
1965

Materials and methods

Principles of method if other than guideline:
other: acute dermal toxicity study
GLP compliance:
no
Test type:
other: acute dermal toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
EC Number:
204-327-1
EC Name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
Cas Number:
119-47-1
Molecular formula:
C23H32O2
IUPAC Name:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
Details on test material:
2,2-methylene-bis-(4-methyl-6-tertiary-butyl phenol)

Test animals

Species:
rabbit
Strain:
other: Albino rabbit (no additional data given)
Sex:
male

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
5 males per dose
Control animals:
not required

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality and clinical signs observed during the study
Clinical signs:
other:

Any other information on results incl. tables

Mortality: none during the study (0/5)

Skin irritation: not observed during the study

Clinical signs: not observed during the study

Gross autopsy: normal

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met