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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study data do not give sufficient experimental details; in addition, it is ambigous if the test design used is suitable for testing the acute inhalation toxicity

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958

Materials and methods

Principles of method if other than guideline:
other: acute inhalation toxicity
GLP compliance:
no
Test type:
other: acute inhalation toxicity

Test material

Constituent 1
Chemical structure
Reference substance name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
EC Number:
204-327-1
EC Name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
Cas Number:
119-47-1
Molecular formula:
C23H32O2
IUPAC Name:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
Details on test material:
no data

Test animals

Species:
other: different species: rabbit, guinea pig, rat, mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
4 h
Concentrations:
4 g of the test substance was heated up to 180°C in a 400 l room
No. of animals per sex per dose:
1 rabbit, 1 guinea pig, 2 rats, 4 mice
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Results:

All animals showed effects on respiration (exacerbate breathing) during exposure

Mortality: 1/1 guinea pig; 0/1 rabbit, 0/2 rats; 0/4 mice

After exposure the animals showed breathing difficulties , which were reversible

Applicant's summary and conclusion