Registration Dossier
Registration Dossier
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EC number: 212-751-3 | CAS number: 866-81-9
Endpoint summary
Administrative data
Description of key information
No NOAECs were identified, neither for rats nor for mice.
LOAEC (local, rat): 0.37 mg/m3 (Tricobalt dicitrate; recalculated value)
LOAEC (local, mouse): 0.37 mg/m3 (Tricobalt dicitrate; recalculated value)
Key value for chemical safety assessment
Additional information
There are no data available on repeated dose toxicity of Tricobalt dicitrate. However, there are reliable data available for the structurally related compound cobalt(II)sulfate heptahydrate. Thus, read-across was conducted based on the structural analogue.
Groups of mice and rats were exposed to cobalt(II)sulfate heptahydrate aerosols by inhalation at concentrations of 0, 0.3, 1, 3, 10, 30 mg/m3 (calculated as anhydrous salt) 6 hours/day, 5 days/week, for 13 weeks (Bucher, 1991).
For rats and mice, lesions seen in the respiratory tract included degeneration of the olfactory epithelium, squamous metaplasia of the respiratory epithelium, and inflammation in the nose. The most sensitive tissue was the larynx, with squamous metaplasia observed also at the lowest exposure concentration of 0.3 mg/m3 (equivalent to 0.15 mg/m3 Tricobalt dicitrate). Thus, no NOAECs were identified, neither for rats nor for mice. The local LOAECs were determined to be 0.3 mg/m3 (equivalent to 0.37 mg/m3 Tricobalt dicitrate) for rats and mice.
Justification for classification or non-classification
There are no data available on repeated dose toxicity of Tricobalt dicitrate. However, there are reliable data available for the structurally related compound cobalt(II)sulfate heptahydrate. Thus, read-across was conducted based on the structural analogue.
Though the respiratory tract was damaged in rats and mice, the test substance will not be classified in repeated dose toxicity since carcinogenic effects in the respiratory tract were observed in a 2 -year inhalation study conducted with cobalt sulfate heptahydrate (NTP, 1998, see carcinogenicity). Therefore, cobalt hydrogencitrate is classified as carcinogenic (DSD: Carcinogenicity category 2; R49; CLP: Carcinogenicity category 1B).
According to CLP, there should be no double classification for the same effect, thus no classification for repeated dose toxicity.
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