Registration Dossier
Registration Dossier
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EC number: 212-751-3 | CAS number: 866-81-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The IC50(9h) for growth inhibition of Tetrahymena pyriformis resulted in a value of 50 mg cobalt/L (recalculated: 156 mg Tricobalt dicitrate/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 156 mg/L
Additional information
Data on single-species toxicity tests resulting in high quality L(I)C50 values (expressed as Co) for microorganisms are summarised in Table 2 of the WHO CICAD document, 2006 (see attached document).
Data on growth inhibition of the protozoan species Tetrahymena pyiformis in 9 hour flask tests were used for the assessment (standard test organism). The IC50(9h) was at 50 mg cobalt/L, resulting in a calculated value of 156 mg Tricobalt dicitrate.
A second study on the ciliate Spirostomum ambiguum showed LC50(24h) values of 11.8 mg cobalt/L using cobalt nitrate as salt, resulting in a value of 37 mg Tricobalt dicitrate/L.
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