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Acute toxicity to fish

As key study regarding acute toxicity to fish a static non-GLP test according to German Industrial Standard DIN 38412 part 15 using Leuciscus idus was identified (BASF 1981). After 96 hours of exposure a LC50 of ca. 460 mg/L was estimated, related to the nominal concentration and for a non-neutralized sample whereas for a neutralized sample a LC50 > 681 mg/L was found.

This result is supported by a study performed by Brixham environmental laboratory according to OECD 203 in 2003 on the seawater fish Scophthalmus maximus (turbot). The LC50 determined was 350 mg/L after 96 hours of exposure. In another study on the marine fish Pleuronectes platessa (Shepherd, 1982) according to OECD 203 the LC50 determined was approximately 290 ppm

These results indicate similar effects on freshwater and salt water as well.

Based on the available data the substance is with high probability not acutely harmful to fish.


Acute toxicity to aquatic invertebrates

To determine the toxicity of 2-(2-aminoethoxy)ethanol to aquatic invertebrates, a static non-GLP study following the method laid down in Directive 79/831/EEC, method C.2 using Daphnia magna was performed. The calculated EC50 (48h) value in this study was >500 mg/L, related to the nominal concentration and for a neutralized sample (BASF SE 1990).

In a test on the marine organism Acartia tonsa according to ISO TC 147/SC5/WG2 by Huntingdon in 1999, the EC50 after 48 hours of exposure was 210 mg/L. 


Toxicity to algae and cyanobacteria

In a non-GLP, 72-hour static test with the green alga Scenedesmus subspicatus ( new name: Desmodesmus subspicatus) according to German Industrial Standard DIN 38412 part 9, the algae toxicity of 2-(2-aminoethoxy)ethanol was investigated. Statistical evaluation of the endpoint growth rate revealed an EC50 (72h) of 202 mg/L, the NOEC was estimated to be 62.5 mg/L.

In a test on the marine algae Skeletonema costatum according to OECD 201 (Huntingdon Life Science, 1999) the ErC50 was determined as > 100 mg/L which was the highest concentration tested.

Further, the substance was tested under marine conditions according to ISO 10253 (Eide-Haugmo, 2009/2012), using Skeletonema costatum as test organism. The 72-h ErC50 was determined to be 493 mg/L.


Toxicity to microorganisms

As key study concerning acute toxicity to microorganisms a test performed by BASF (1990) according to German Industrial Standard DIN 38412 part 8 was identified, using Pseudomonas putida as test organism. In the static test an EC10 of 28 mg/L after 17 hours of exposure was calculated.

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