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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1976
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
Dose was not provided. Source, purity, chemical characteristics of test substance, temperature, light cycle, and humidity not provided; quantitative results not provided
GLP compliance:
no
Remarks:
study pre-dates GLP requirements
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-triazole
EC Number:
206-022-9
EC Name:
1,2,4-triazole
Cas Number:
288-88-0
Molecular formula:
C2H3N3
IUPAC Name:
1H-1,2,4-triazole
Details on test material:
- Name of test material (as cited in study report): 1,2,4-triazole
- Analytical purity: reported as technically pure

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: from the breeder Winkelmann (Borchen)
- Age at study initiation: no data
- Weight at study initiation: 18-22g
- Fasting period before study: no data
- Housing: in tyupe-III Makrolon cages
- Diet (e.g. ad libitum): Altromin R standard diet, ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
The inhalation was carried out in 10 litre inhalation chambers. Air was passed at 2 litres per minutes through test article in a dust tower. The resulting air, enriched with vapor and dust was administered to the animals for inhalation.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Not reported
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
14 -day post observation period

Results and discussion

Mortality:
None
Clinical signs:
other: Mice tolerated the 6 hour inhalation without signs. No irritant effect on the mucous membrane of the eyes and noses of the animal was observed.

Applicant's summary and conclusion

Interpretation of results:
other: No dosage was reported, unable to classify.