Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Nasal irritation and pulmonary toxicity of aliphatic amines in mice
- Author:
- Gagnaire F, Azim S, Bonnet P, Simon P, Guenier JP, de Ceaurriz J
- Year:
- 1 989
- Bibliographic source:
- J Appl Toxicol 9, 301-304
Materials and methods
- Principles of method if other than guideline:
- Male mice were exposed head only to different concentrations of cyclohexylamine for 15 min and breathing frequency was measured using body plethysmography to determine the concentration causing a 50 % decrease in the respiratory rate (RD50)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- the chemical was obtained as high-purity liquid (no further details)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
Test system
- Route of induction exposure:
- inhalation
- Vehicle:
- other: air
- Concentration:
- 26-84 ppm (approx. 107-346 mg/m³)
- No. of animals per dose:
- 6
Results and discussion
- Results:
- cyclohexylamine was evaluated to have minor irritant potency as the RD50 was 51 ppm (approx. 210 mg/m³)
Applicant's summary and conclusion
- Executive summary:
Male Swiss mice were exposed head-only to 26 -84 ppm ( approx.107 -346 mg/m³) vaporized cyclohexylamine for 15 min. A concentration of 51 ppm (approx. 210 mg/m³) caused a 50 % decrease in the respiratory rate (Gagnaire 1989).
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