Registration Dossier
Registration Dossier
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EC number: 297-648-1 | CAS number: 93685-99-5 Oil shale waste is produced by thermal processing in a fluidized bed process at 800°C from mining exhausted oil shale. Oil shale waste consists essentially of Al2O3, CaO, CaSO4, Fe2O3 and SiO2.
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed data
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Experimental study of silica absorption through the digestive tract as a cause of extrapulmonary silicosis
- Author:
- González Huergo, D. and Rojo Ortega, D.
- Year:
- 1 991
- Bibliographic source:
- Rev Esp Enferm Dig, 80(2):95-98, as cited in: NTP. 2009. Chemical Information Review Document for Silica Flour (Micronized α-Quartz). U.S Department of Health and Human Services
Materials and methods
- Objective of study:
- absorption
- distribution
- Principles of method if other than guideline:
- Absorption and distribution of silica particles in rats after administration via stomach tube
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quartz (SiO2)
- EC Number:
- 238-878-4
- EC Name:
- Quartz (SiO2)
- Cas Number:
- 14808-60-7
- Molecular formula:
- O2Si
- IUPAC Name:
- dioxosilane
- Details on test material:
- - Name of test material (as cited in study report): silica particles
- Analytical purity: no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- other: stomach tube
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to six doses of 50 mg
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Silica particles were not observed in the submucosa, muscularis or regional lymph nodes. The liver and the spleen did not show silicotic nodules. The healthy gastrointestinal barrier plays hardly any part in both silica absorption and extrapulmonary silicosis.
Applicant's summary and conclusion
- Conclusions:
- The healthy gastrointestinal barrier plays hardly any part in both silica absorption and extrapulmonary silicosis.
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