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EC number: 266-582-5 | CAS number: 67124-09-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
This substance is not irritating to skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation (comparable to OECD TG 404)
In a key study this substance was applied to an abraded and an intact site on each white rabbits under semi-occlusive dressing for 24 hours (Costello, 1982). Six animals were tested in the study. Evaluation was made on the arithmetic mean of all animals. The primary irritation was determined to be 0.84. According to the conclusion of the study, the substance is not irritating to skin.
Eye irritation (similar to OECD TG 405)
In a key study, 0.1 mL test substance was instilled into the conjunctival sac of white rabbits (Costello, 1982). The test material was not washed from the eyes.The eyes were examined and graded for ocular reaction at 1h, and 1, 2, 3, 4, 7 days following instillation of test material into the eyes. The overall primary ocular irritation index was 0.7 and the test substance was unlikely to be an ocular irritant in the test animals.
Justification for classification or non-classification
Skin irritation
Since 6 animals were tested, the evaluation of test results was performed according to the Example 3b (section 3.2.6.1.4. in the ECHA "Guidance on the Application of the CLP Criteria", 2009). According to this approach the average score is determined per animal. In this case, if 4 of 6 animals reached a cut-off value of 2.3 or above at 24, 48 and 72 hours after patch removal, the classification as Skin Irritant is assigned. The highest mean value for erythema/eschar and for oedema was 1.0 in animal No.3. The mean values for other animals were all lower than 1.0. Therefore, this substance does not meet the requirement under EU CLP (Regulation (EC) No. 1272/2008) for classification as a skin irritant.
Eye irritation
In case of 6 rabbits, classification as eye irritant triggers if at least 4 ot 6 rabbits show a mean score of ≥ 1 for the cornea and/or for iris and ≥ 2 for conjunctival erythema and/or conjunctival swelling. In the eye irritation study, the mean score of 0.0 was for cornea and for iris in all animals grading at 24, 48 and 72 hours after instillation. The mean score of 0.33 was for conjunctival erythema and for conjunctival swelling only in one animal. Thefore, the substance does not meet classification criteria under EU CLP (Regulation (EC) No. 1272/2008) as eye irritant.
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