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EC number: 273-066-3 | CAS number: 68937-41-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975, not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, not carried out according to recognised guideline, although results documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as outlined i n 16 CFR 1500.3
- Deviations:
- not specified
- Principles of method if other than guideline:
- Test substance was administered by inhalation as supplied by the sponsor and aerosolised to 5 male and 5 female rats. Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :
Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phenol, isopropylated, phosphate (3:1)
- EC Number:
- 273-066-3
- EC Name:
- Phenol, isopropylated, phosphate (3:1)
- Cas Number:
- 68937-41-7
- Molecular formula:
- CXHYO4P X and Y are variable dependant on the molecular component.
- IUPAC Name:
- Phenol, isopropylated, phosphate (3:1)
- Details on test material:
- Specified only as Product No . X-50; Kronitex 50 ; Lot 5-101.
No other information on the test material is provided within the report.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The test utilised ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g. No other information is detailed.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :
Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 200 mg/l
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- Ten adult albino rats (wistar-derived strain ) equally distributed into five males and five females weighing between 200-300g were exposed to the test material administered as a volume of gas or vapor for one hour in an all glass (72 liter) chamber under the following conditions :
Air Flow: 10 liters per minute
Weight of material aerosolized: 2 g/minute
Nominal concentration of test material: 200 mg per Liter - Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- 1 death on Day 7.
- Clinical signs:
- other: No data.
- Body weight:
- No data.
- Gross pathology:
- No findings.
- Other findings:
- No acute symptoms were observed prior: to death. Gross examination at autopsy of the one animal that died revealed no noteworthy findings.
Any other information on results incl. tables
Mortality data
Dose level mg/l |
No. rats dosed |
deaths per day |
Mortality after 14 days |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
|||
200 |
5M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/5 |
200 |
5F |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1/5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance demonstrated a 10% mortality rate and has been completed as a limit test at 200 mg/l The LD50 is considered to be >200 mg/l.
- Executive summary:
The test sample was dosed by inhalation to 5 male and 5 female rats at a dose of 200 mg/l. Assessed over a 14 day period, 0 male and 1 female deaths occurred and the study was completed as a limit test. The LC50 is considered >200 mg/l.
No classification is applicable based on the results.
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