Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
440-850-3
EC Name:
-
Cas Number:
27311-52-0
Molecular formula:
C13H14N2O2.2ClH
IUPAC Name:
4-amino-2-[(5-amino-2-hydroxyphenyl)methyl]phenol dihydrochloride
Constituent 2
Reference substance name:
[TN]Ro 1525[/TN][SPEC][/SPEC][AM]99 %[/AM]
IUPAC Name:
[TN]Ro 1525[/TN][SPEC][/SPEC][AM]99 %[/AM]
Details on test material:
Batch: 3962-88

Results and discussion

Water solubility
Water solubility:
183 g/L
Temp.:
30 °C
pH:
1.38

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
Solubility in water = 183 g/L at 30°C and pH 1.4