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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
yes
Remarks:
Test performed at pH 7.
GLP compliance:
no
Radiolabelling:
no
Transformation products:
yes
No.:
#1
No.:
#2
Details on hydrolysis and appearance of transformation product(s):
After 1 hour, the formation of N,N diethyl amino propionic acid (MW: 145 g/mol; C7H15O2N) reached its maximum concentration (57% w of DEA-AA correspond to ca. 90% hydrolysis).
Key result
pH:
4
Temp.:
25 °C
DT50:
104 d
Key result
pH:
7
Temp.:
25 °C
DT50:
11 h
Key result
pH:
9
Temp.:
25 °C
DT50:
< 1 h

In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Also, degradation half-life decreased with increasing temperature at pH7.

Conclusions:
Under the test conditions, the test substance was subject to hydrolysis at pH 7, 24.1°C (into DEA-AA and TPG).
Executive summary:

A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods.

In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9.

The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG).

Description of key information

A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods. In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9. This corresponds to a half-life of 1.3 d at 12°C (pH 7). The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG) (Parent, 2007).

Key value for chemical safety assessment

Half-life for hydrolysis:
11 h
at the temperature of:
25 °C

Additional information