2-Propenoic acid, (1-methyl-1,2-ethanediyl) bis[oxy(methyl-2,1-ethanediyl)] ester, reaction products with diethylamine

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July, 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

yes

Remarks:

Test performed at pH 7.

GLP compliance:

no

Radiolabelling:

no

Transformation products:

yes

No.:

#1

No.:

#2

Details on hydrolysis and appearance of transformation product(s):

After 1 hour, the formation of N,N diethyl amino propionic acid (MW: 145 g/mol; C7H15O2N) reached its maximum concentration (57% w of DEA-AA correspond to ca. 90% hydrolysis).

Key result

pH:

4

Temp.:

25 °C

DT50:

104 d

Key result

pH:

7

Temp.:

25 °C

DT50:

11 h

Key result

pH:

9

Temp.:

25 °C

DT50:

< 1 h

In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Also, degradation half-life decreased with increasing temperature at pH7.

Conclusions:

Under the test conditions, the test substance was subject to hydrolysis at pH 7, 24.1°C (into DEA-AA and TPG).

Executive summary:

A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods.

In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9.

The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG).

Description of key information

A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods. In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9. This corresponds to a half-life of 1.3 d at 12°C (pH 7). The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG) (Parent, 2007).

Key value for chemical safety assessment

Half-life for hydrolysis:

11 h

at the temperature of:

25 °C