Manganese di(acetate)

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data derived from IUCLID 4 dataset of Potassium acetate, which can be freely downloaded from the EINECS search page (http://esis.jrc.ec.europa.eu/). Only basic data given, no further information can be retrieved.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

2000

Report date:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

not specified

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Potassium acetate

EC Number:

204-822-2

EC Name:

Potassium acetate

Cas Number:

127-08-2

Molecular formula:

C2H4O2.K

IUPAC Name:

potassium acetate

Test material form:

other: solution

Details on test material:

- Name of test material (as cited in study report): potassium acetate
- Substance type: solution of the compound
- Physical state: liquid (solved)

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

other: vehicle used, probably water

Controls:

not specified

Amount / concentration applied:

no data

Duration of treatment / exposure:

no data

Observation period (in vivo):

no data

Number of animals or in vitro replicates:

no data

Details on study design:

no data

Results and discussion

In vivo

Results

Irritation parameter:

other: individual mean score

Basis:

other: mean score of each animal

Time point:

other: no data

Score:

< 2.5

Reversibility:

fully reversible

Remarks:

Redness and swelling were transient.

Remarks on result:

other: Although described as slightly irritating in the report, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test.

Irritant / corrosive response data:

Result: slightly irritating
EC classification: not irritating
Redness and swelling were transient and individual mean scores were less than 2.5. Although described as slightly irritating in the report, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The outcome of the test was that Potassium acetate is slightly irritating to the eye. But the authors concluded that, since the individual mean scores were less than 2.5, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test. Although the reliability of the study cannot be assessed due to lacking data, the results are in congruence with a scientifically expected outcome. Hence, the effects are not sufficient to classify Potassium acetate as eye irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.

Executive summary:

A solution of Potassium acetate was tested in a OECD 405 guideline study in rabbits for its eye irritating potency. The the individual mean scores were less than 2.5, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' in rabbits are not met by the results of this test. Hence, the effects are not sufficient to classify Potassium acetate as eye irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.