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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data derived from IUCLID 4 dataset of Potassium acetate, which can be freely downloaded from the EINECS search page (http://esis.jrc.ec.europa.eu/). Only basic data given, no further information can be retrieved.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium acetate
EC Number:
204-822-2
EC Name:
Potassium acetate
Cas Number:
127-08-2
Molecular formula:
C2H4O2.K
IUPAC Name:
potassium acetate
Test material form:
other: solution
Details on test material:
- Name of test material (as cited in study report): potassium acetate
- Substance type: solution of the compound
- Physical state: liquid (solved)

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
other: vehicle used, probably water
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
other: individual mean score
Basis:
other: mean score of each animal
Time point:
other: no data
Score:
< 2.5
Reversibility:
fully reversible
Remarks:
Redness and swelling were transient.
Remarks on result:
other: Although described as slightly irritating in the report, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test.
Irritant / corrosive response data:
Result: slightly irritating
EC classification: not irritating
Redness and swelling were transient and individual mean scores were less than 2.5. Although described as slightly irritating in the report, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The outcome of the test was that Potassium acetate is slightly irritating to the eye. But the authors concluded that, since the individual mean scores were less than 2.5, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' are not met by the results of this test. Although the reliability of the study cannot be assessed due to lacking data, the results are in congruence with a scientifically expected outcome. Hence, the effects are not sufficient to classify Potassium acetate as eye irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.
Executive summary:

A solution of Potassium acetate was tested in a OECD 405 guideline study in rabbits for its eye irritating potency. The the individual mean scores were less than 2.5, the criteria for classification as R36 (i.e. H319) 'irritating to eyes' in rabbits are not met by the results of this test. Hence, the effects are not sufficient to classify Potassium acetate as eye irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.

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