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Toxicity to other aquatic organisms

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Description of key information

Spirostomum ambiguum: EC50 (24h) 287.5 ± 138.5 mg/L, EC50 (48h) 337.7 ± 205.4 mg/L, LC50 (24h) 458.6 ± 48.0 mg/L and LC50 (48h) 452.4 ± 60.4 mg/L, based on occurrence of different deformations resp. lethal response , corrected for manganese (II) acetate.
Tetrahymena pyriformis: EC50 (1h) 83.5 mg/L and the IC50 (9h) 650.6 mg/L, based on metabolic activity resp. growth inhibition, corrected for manganese (II) acetate

Additional information

There are two studies available on other aquatic organisms, conducted with the manganese cation. Although no mandatory endpoint under REACH, these studies on protozoae can be used to support the conclusion drawn in IUCLID chapter 6.1.5 "Toxicity on aquatic plants and cyanobacteria".

Within the two available studies, the information gained from Spirostomum ambiguum are considered to be the more reliable ones because the test duration was up to 48 h instead of 9 h, and results in the more sensitive response.

Since also both studies were assessed to be reliable with restrictions, the results can considered to be trustworthy. Since Spirostomum ambiguum serves as an additional species to assess the possible hazard of the test item to the environment, the same criteria for classification or non-classification should apply as for algae and other aquatic plants.

Taking into account the retrieved results, i.e. EC50 (24h) 287.5 ± 138.5 mg/L, EC50 (48h) 337.7 ± 205.4 mg/L, LC50 (24h) 458.6 ± 48.0 mg/L and LC50 (48h) 452.4 ± 60.4 mg/L, based on occurrence of different deformations resp. lethal response , corrected for manganese (II) acetate from the free cation, it can be assumed that the EC50 and LC50 values after 72 h are unlikely to be significantly lower. As Manganese (II) acetate as an inorganic salt has no potential for bioaccumulation and is no subject to biodegradation, Manganese (II) acetate does not need to be classified as hazardous to the aquatic environment.

This result is in congruence with the results obtained from the toxicity study in algae.

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