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EC number: 253-138-0 | CAS number: 36631-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 22 March - 25 April 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study conducted in accordance with recognised test methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- - reduced numbers of animals used (10 rather than 20 in test group), no control animals
- Principles of method if other than guideline:
- Ten male guinea pigs, weighing 300-400 g were used to assess the contact dermal irritation/sensitisation potential of Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM. The animals were housed & maintained in compliance with the animal welfare act (Pub. L-94-279) 9CFR part 3. ). TOTM was applied to intact skin sites and left in contact for 24h. TOTM was applied a second time on the same sites on day 3 and the sequence was repeated for a total of 10 applications. The animals were untreated for 2 weeks after which a challenge dose was applied to new skin sites for 24h . Twenty -four h after each application in the induction phase and 24 & 48h after the challenge application the sites were examined for signs of irritation and any findings scored using the Draize method.
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- EC Number:
- 222-020-0
- EC Name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Cas Number:
- 3319-31-1
- IUPAC Name:
- tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Details on test material:
- - Name of test material (as cited in study report): Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM
Used as supplied
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: Not reported
- Weight at study initiation: 300-400 g
- Housing: Stainless steel cages with elevated wire mesh flooring
- Diet (e.g. ad libitum): ad libitum, Charles River Guinea pig Formula,
- Water (e.g. ad libitum): ad libitum, tap water
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 70 +/-2 degrees F
- Humidity (%): 45+/-5
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12:12
IN-LIFE DATES: From: 21 September To: 28 October 1981
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction phase: neat Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM
Challenge phase: Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Induction phase: neat Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM
Challenge phase: Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM
- No. of animals per dose:
- 10
- Details on study design:
- RANGE FINDING TESTS: No data
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 10
- Exposure period: 24 h
- Test groups: 1
- Control group: 0 (none)
- Site: Not specified
- Frequency of applications: 10 with a 24h recovery period between them
- Duration: Until Tris (2-ethylhexyl)trimellitate/Nuoplaz 6959/TOTM had been applied 10 times
- Concentrations: 0.5 ml of 100%/neat TOTM
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 2 weeks after 10th sensitising/induction application
- Exposure period: 24 h
- Test groups: 1
- Control group: 0 (none)
- Site: No data
- Concentrations: 100%, used as supplied
- Evaluation (hr after challenge): 24 & 48h
OTHER: - Challenge controls:
- None used
- Positive control substance(s):
- no
Study design: in vivo (LLNA)
- Statistics:
- None
Results and discussion
- Positive control results:
- None no positive control group on study
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100% TOTM
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 100% TOTM. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No data.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100% TOTM
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 100% TOTM. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No data.
Any other information on results incl. tables
Induction score : 0.0
Topical challenge scores
after 24 h:0.0
After 48h :0.0
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this test, read-across substance, tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate, is not a primary irritant, fatiguing agent or skin sensitiser in the albino guinea pig. No skin reactions were seen during the induction (sensitising) phase or subsequent challenge phase.
- Executive summary:
Delayed dermal sensitisation has been assessed using the Buehler method.
No sensitisation response was reported at challenge following a period of induction exposures to the substance
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