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EC number: 277-362-3 | CAS number: 73296-89-6
Table 1: Data availability for toxicokinetics, metabolism and distribution
C11ASO4KCAS not available
Table 2: Metabolites formed from alkyl sulfates with even chain length*
4-butyrolactone (ring structure)
Glycolic acid sulfate
Major MetaboliteFound in rats, dogs, humans
Minor metaboliteFound in rats, dogs, humans
Minor metaboliteFound in dogs (and humans)
* investigated substances were potassium salts of C10, C12, C14& C18alkyl sulfates
Table 3: Influence of chain length on elimination of alkyl sulfates
Number of animals, sex*
Recovery from urine at 48 h (% of dose)*
Recovery from feces at 48 h (% of dose)*
Recovery from carcass at 48 h (% of dose)*
* mean number of number of animals indicated, all values are mean values; ** n.a. = not available; 5 mg/kg bw of the35S labeled compounds was applied i.p. to MRC rats
The toxicokinetic behaviour of alkyl sulfates was assessed. Alkyl sulfates are well absorbed after ingestion. After absorption, these chemicals are distributed mainly to the liver. Alkyl sulfates are metabolized by cytochrome P450-dependent w-oxidation and subsequent beta-oxidation of the aliphatic fatty acids. End products of the oxidation are a C4sulfate and a C3or C5sulfate. In addition, for the alkyl sulfates, sulfate is formed as a metabolite. The metabolites are rapidly excreted in urine. Due to the low concentrations of the substances in consumer products and the limited uptake after dermal exposure which is the main route for consumers, significant exposure of the developing foetus via the placenta or the neonate via the breast milk is not likely. Therefore a bioaccumulation of alkyl sulfates is not expected.
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