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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

At the current state of knowledge, a significant potential to bioaccumulate is not to be expected.

Key value for chemical safety assessment

Additional information

For the assessment of the bioaccumulative potential of CAS 2440-22-4 one study according to OECD TG 305C is available. This study was conducted at the Safety Center for Chemicals, Kurume Institute, Chemicals Inspection & Testing Inst., Japan from 1997 to 1998. Japanese rice fish (Oryzias latipes) were exposed to three concentrations of the test compound (1, 0.1, and 0.01 mg/L) in a semi-static test design for 8 weeks without a subsequent depuration phase. The stock solutions were prepared with 20-fold HCO-20 (w/w) and 20-fold olive oil (w/w) as solubilizer. Two fish from each concentration group were sampled at weeks 2, 4, 6, and 8 and analyzed for the test compound. The resulting BCF values ranged from 123-494 L/kg, 130-295 L/kg, and 44-220 L/kg for the test groups 1, 0.1, and 0.01 mg/L, respectively.

Additionally, toxicokinetic studies in rat showed, that the test substance will be metabolized. It is expected that the phenolic hydroxy group will be conjugated with glucuronic acid or sulfonic acid in both liver and extrahepatic tissues. Oxidative metabolism at the methyl group is also possible. A specific investigation on effects on liver (Schmid 1980 and Lake (undated)) showed that the substance induces UDP-glucuronosyltransferases, but no microsomal oxidases in rat liver of both sexes.

At the current state of knowledge, a significant potential to bioaccumulate is not expected. However, the available experimental study on carp has some deficiencies which could result in an underestimation of the bioaccumulative potential. Therefore, to have final clarity on the bioaccumulative potential a BCF study according to the latest OECD 305 guideline is proposed.