Registration Dossier
Registration Dossier
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EC number: 229-194-7 | CAS number: 6425-39-4
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-07-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well performed GLP study in accordance with OECD Guideline 112.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: PFW100113
- Analytical purity: 99.3% (by GC)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: the sample is stored in cool, well-ventilated storage area prior to testing.
OTHER SPECIFICS:
- Name of test material (as cited in study report): Jeffcat DMDEE
- Physical state: Liquid - Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 6.8
- Temp.:
- 20 °C
- Remarks on result:
- other: No details on temperature are provided, however ambient temperature is anticipated
- Conclusions:
- The dissociation constant of the substance was determined to be 6.8 ± 0.5.
Reference
Description of key information
The dissociation constant of the test substance was determined to be 6.8 at ambient temperature following a GLP study conducted in accordance with guideline OECD 112 using the titration method (Younis, 2011).
Key value for chemical safety assessment
- pKa at 20°C:
- 6.8
Additional information
Although the temperature was not reported it was assumed that the study was conducted at ambient temperature.
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