Registration Dossier
Registration Dossier
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EC number: 202-879-8 | CAS number: 100-69-6
Carcinogenicity
Administrative data
Description of key information
A weight of evidence approach was utilized to review experimental tumorigenicity data, modeled carcinogenicity predictions, and mutagenicity data on 2VP. The conclusion is that 2VP is not carcinogenic.
Key value for chemical safety assessment
Justification for classification or non-classification
Experimental evidence and predictive models of carcinogenesis indicate that 2-vinylpyridine is not carcinogenic.
Additional information
2-Vinylpyridine was investigated in a lung adenoma model (20-week exposure in mice) and found not to induce lung tumors. It was also evaluated in a validated structure-activity relationship (SAR) model for carcinogenicity based on the Carcinogenic Potency Data Base of Gold. This model, which is based on molecular substructures of carcinogen and noncarcinogens, predicts that 2 -VP is not carcinogenic (is inactive). Furthermore, 2VP is not considered mutagenic, which is one of several critical behaviours which can precede development of cancers. In summary, there is insufficient evidence to suggest that 2VP is a carcinogenic substance.
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