Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 202-879-8 | CAS number: 100-69-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This is a case report. As such, a publication in a journal dedicated to publication of case reports, is not evidence of a causal relationship between adverse effect and chemical exposure.
Data source
Reference
- Reference Type:
- publication
- Title:
- Cutaneous and systemic sequelae from exposure to 2-vinylpyridine
- Author:
- Rajpar SF, Jackson JR and Foulds IS
- Year:
- 2 006
- Bibliographic source:
- Contact Dermatitis 55:374-375
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Case report of a single exposure of a worker to 2-vinylpyridine
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- No information other than occupational exposure in a chemical production factory.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Subjects:
- one case
- Route of administration:
- dermal
- Details on study design:
- Poorly defined exposure to chemical subtance(s).
Results and discussion
- Results of examinations:
- 48-72 hours after presumed cutaneous exposure to chemicals, the worker developed severe dermatitis with secondary eczematization, and nausea and light-headedness. The systemic symptoms resolved over 48 additional hours, while the dermatitis took a week to resolve. He underwent clinical patch testing to a variety of chemicals, including 2VP in methyl ethyl ketone at 0.1%, 0.5%, and1%. The tested positive to the two higher concentrations, but not to the 0.1% concentration.
Applicant's summary and conclusion
- Conclusions:
- This is a report of a case of reversible contact dermatitis in a chemical factory worker exposed via skin to 2-vinylpyridine. Systemic symptoms (nausea and lightheadedness) occurring 48-72 hours after the exposure most likely are unrelated to the chemical exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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