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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Monomeric methyl methacrylate studies on toxicity
Author:
Spealman C.R., Main R.J., Haag H.B., Larson P.S.
Year:
1945
Bibliographic source:
Ind. Med. 14: 292-298

Materials and methods

Principles of method if other than guideline:
Study to assess the acute inhalative toxicity in mice.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
3 h

Results and discussion

Effect levelsopen allclose all
Key result
Dose descriptor:
LC50
Effect level:
55 mg/L air
Exp. duration:
3 h
Remarks on result:
other: 55.0 mg/L equals 13220 ppm
Dose descriptor:
LC100
Effect level:
61.8 mg/L air
Exp. duration:
3 h
Remarks on result:
other: 61.8 mg/L equals 14860 ppm
Dose descriptor:
other: LC5
Effect level:
26.2 mg/L air
Exp. duration:
3 h
Remarks on result:
other: 26.2 mg/L equals 6300 ppm
Dose descriptor:
other: LC13
Effect level:
47.7 mg/L air
Exp. duration:
3 h
Remarks on result:
other: 47.7 mg/L equals 11470 ppm

Applicant's summary and conclusion