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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reference do not give sufficient experimental details: longer exposure time than recommended by OECD 404, 2002; no details on test material, test animals and little information on administration
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1955

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The day before administration the eight albino rabbits were clipped over the entire trunk, care being taken to avoid cutting or abrading the skin. A single dose of 25g antimony trioxide dust incorporated in aqueous methylcellulose paste was applied to the denuded skin. The test site areas were about two-thirds of the animals`torso. They were covered by an impervious membrane (Vinylite). The test item was applied for one week. After exposure local skin reactions and signs of systemic toxicity were examined.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
other: albino rabbits
Strain:
not specified
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped over the entire trunk without cutting the skin
Vehicle:
other: aqueous methylcellulose paste
Controls:
not specified
Amount / concentration applied:





TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 25 g of antimony trioxide dust incorporated in aqueous methylcellulose paste
- Concentration (if solution): not stated


VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity:not stated
Duration of treatment / exposure:
one week
Observation period:
not stated
Number of animals:
eight albino rabbits
Details on study design:
TEST SITE
- Area of exposure: The Methylcellulose paste was applied to the intact skin of two-thirds of the animals' torso.
- Type of wrap if used: The area was covered by an impervious membrane (Vinylite).

Results and discussion

In vivo

Results
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No significant local reaction.
Other effects:
No apparent sign of systemic toxicity.

Any other information on results incl. tables

No significant local reaction. No apparent sign of systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
No significant local reaction.