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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From April 3rd to 23rd, 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
1981
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Blue REg 6080
IUPAC Name:
Blue REg 6080

Study design

Analytical monitoring:
yes
Details on test conditions:
A preliminary test was performed at 50 ± 0.5 °C at each of pH 4, 7, 9.
Aliquots of each test solution were analysed in time intervals using the HPLC-UV analytical method. Analysis was performed before incubation, after 2.4 hours and after 120 hours.
Number of replicates:
Duplicate for each pH.

Results and discussion

Preliminary study:
The solubility of test item in buffer solution pH 4, 7 and 9 is very low. It was not possible to increase the soluble amount of test item with the use of solubilizer. Peak obtained, if any, are too small to allow quantification or even to follow a degradation curve.
As test item showed no significant solubility, no further testing was performed.
Transformation products:
not measured
Dissipation DT50 of parent compound
Remarks on result:
not determinable
Remarks:
due to the low solubility of test item
Details on results:
No test could be performed. The solubility of the test item in the buffer solutions at pH 4, 7 and 9 is very low. It was not possible to increase the soluble amount of the substance by the use of a solubilizer. Peak obtained, if any, are too small to allow quantification or even to follow a degradation curve.

Applicant's summary and conclusion

Conclusions:
No test could be performed as test item has too little water solubility to be evaluated for hydrolytic stability under test conditions.