Registration Dossier
Registration Dossier
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EC number: 203-826-1 | CAS number: 111-02-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Squalane and Squalene
- Author:
- CIR Expert panel
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology 1982 1: 37
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Act (FHSA
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Squalane
- IUPAC Name:
- Squalane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Sherman
Administration / exposure
- Route of administration:
- other: spray formulation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 345 mg/L
- No. of animals per sex per dose:
- 5 x sex x dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 9.1 other: mg/kg
- Based on:
- test mat.
- Exp. duration:
- 1 h
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Autopsy 14 days after exposure revealed no abnormalities. LC0= 9.1 mg/kg bw
- Executive summary:
The similar substance has been tested for acute inhalation toxicity on rats. The acute dose of 9.1 mg/kg doesen't show any abnormalities.
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