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Registration Dossier
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EC number: 203-826-1 | CAS number: 111-02-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Squalane and Squalene
- Author:
- CIR Expert panel
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology 1982 1: 37
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- EC Number:
- 203-826-1
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Cas Number:
- 111-02-4
- Molecular formula:
- C30H50
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Test material form:
- other: liquid
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5.0, 12.5, 25.0, 50.0 ml/kg
- No. of animals per sex per dose:
- groups with 5, 5, 10 and 10 mice
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 50 mL/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 mL/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical signs observed
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the seven-day observation period, no toxic effects were observed and no deaths occurred. The single dose oral LD50 was determined to be greater than 50 ml/kg in mice.
- Executive summary:
Squalene has been tested for acute oral toxicity on mice. The single dose oral LD50 was determined to be greater than 50 ml/kg.
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