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EC number: 297-797-2
CAS number: 93762-80-2
irritation in humans (7 male and 9 female) after exposure to 1-octene
(at concentrations of 0, 1307, 2266, and 3922 parts per million) was
examined in this study, in order to evaluate cytological changes and
conjunctival hyperemia. Human volunteers were exposed to 1-octene once a
week for 5 weeks, and photos and conjunctival fluid samples were used to
assess effects. Overall, as the exposure concentration increased, the
perceived irritation intensity and conjunctival hyperemia
increased. Changes in conjunctival hyperemia were significant at the
highest dose of 1-octene, whereas “total irritation” and “average
irritation” were significantly correlated to the exposure
concentration. Perceived irritation, changes in conjunctival hyperemia,
and exposure concentrations were unrelated to cytological changes in the
conjunctival fluid samples.
study is classified as reliable with restrictions because it provides no
data on GLPs and did not follow Guidelines, but does provide study
protocol and results.
study was selected as a supporting study because it received a
lower Klimisch score than the selected key study; however, this
study contains relevant and useful data, allowing it to qualify as
a supporting study.
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