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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The bioconcentration factor (BCF) of the test substance was evaluated with BCFBAF model v3.01 from EPI Suite v4.1, which fulfilled all OECD principles. Test substance is within the domain of the BCFBAF model based on the molecular weight and fragments present in the BCFBAF database.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Principles of method if other than guideline:
QSAR calculation
GLP compliance:
no
Radiolabelling:
no
Vehicle:
no
Test type:
other: QSAR
Type:
BCF
Value:
372 L/kg
Basis:
whole body w.w.

Log Kow (estimated) : 4.66

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 4.40 (user entered)

 

Equation Used to Make BCF estimate:

  Log BCF = 0.6598 log Kow - 0.333 + Correction

 

No Applicable Correction Factors

 

Estimated Log BCF = 2.570 (BCF = 372 L/kg wet-wt)

Validity criteria fulfilled:
yes
Conclusions:
The BCF of the test substance was 372 L/Kg whole body weight, corresponding to a log BCF = 2.57
Executive summary:

The bioconcentration factor (BCF) of the test substance was evaluated with BCFBAF model v3.01 from EPI Suite v4.1, which fulfilled all OECD principles. Test substance is within the domain of the BCFBAF model based on the molecular weight and fragments present in the BCFBAF database.

The BCF of the test substance was 372 L/Kg whole body weight, corresponding to a log BCF = 2.57

Description of key information

The BCF of the test substance was estimated by QSAR as 372 L/Kg whole body weight, corresponding to a log BCF = 2.57

Key value for chemical safety assessment

BCF (aquatic species):
372 L/kg ww

Additional information

As no refinement is necessary for B-assessment (Log Kow value < 4.5) or for chemical safety assessment, the aquatic bioaccumulation was estimated by calculation.

 

The following result was obtained: the BCF of the test substance was 372 L/Kg whole body weight, corresponding to a log BCF = 2.57