Registration Dossier

Administrative data

Description of key information

The substance do not show any repeated dose toxicity. 

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LOAEL
735.11 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Quality of whole database:
predicted data

Additional information

Repeated dose - oral category:

Repeated dose LOEL effect on rat for methyl 5-nitrohydrogen.isophthalate is found to 735.11 mg/kg/day

Repeated dose - inhalation category:

Repeated dose LOEL effect on rat for methyl 5-nitrohydrogen.isophthalate is found to 52.64 mg/kg/day

Repeated dose - dermal category:

According to annex IX of REACH regulation, Short-term repeated dose toxicity study (28 days) does not need to be conducted if one species, male and female, most appropriate route of administration, having regard to the likely route of human exposure, unless already provided as part of Annex VIII requirements. since acute toxicity dermal route has been provided as part of annex VIII requirements.

Justification for classification or non-classification