Registration Dossier
Registration Dossier
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EC number: 203-788-6 | CAS number: 110-65-6
Endpoint summary
Administrative data
Description of key information
Oral LD50 = 132 mg/kg bw
Dermal LD50 = 659 mg/kg bw
Inhalation LC50 = 690 mg/m3
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 132 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 690 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 659 mg/kg bw
Additional information
1,4 -Butynediol (B3D) has been adequately characterized for acute toxicity via oral, dermal, and inhalation routes. In various GLP and non-GLP guideline studies, the oral LD50 (male rats) was determined to be 132 mg/kg bw (Jedrychowsi, et. al., 1992), the dermal LD50 (male/female rats) was determined to be 659 mg/kg bw (BG Chemie, 1990), and the inhalation LC50 (male/female rats) was determined to be 690 mg/m3 (BG Chemie, 1996).
Justification for classification or non-classification
Acute oral toxicity
Based on the results of acute oral toxicity testing (LD50, rat = 132 mg/kg-bw), the substance should be classified as T; R25 (Toxic if swallowed) under the EU DSD classification criteria (EU Directive 67/548/EEC) and Acute Toxicity, Oral-Category 3 under the EU CLP classification criteria (Regulation (EC) 1272/2008).
Acute inhalation toxicity
Based on the results of acute inhalation toxicity testing (LC50, rat = 0.690 mg/l), the substance should be classified as T; R23 (Toxic by inhalation) under the EU DSD classification criteria (EU Directive 67/548/EEC) and Acute Toxicity, Inhalation-Category 3 under the EU CLP classification criteria (Regulation (EC) 1272/2008).
Acute dermal toxicity
Based on the results of acute dermal toxicity testing (LD50, rat = 659 mg/kg-bw) the substance should be classified as Xn; R21 (Harmful in contact with skin) under the EU DSD classification criteria (EU Directive 67/548/EEC) and Acute Toxicity, Dermal-Category 3 under the EU CLP classification criteria (Regulation (EC) 1272/2008). Regulation (EC) 1272/2008, Annex VI, specifies a minimum classification of Category 4 unless the manufacturer has data that a higher classification is necessary, as in this case.
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