But-2-yne-1,4-diol

Toxicity to other above-ground organisms

Administrative data

Endpoint:

toxicity to other above-ground organisms

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented publication which meets basic scientific principles. Not suitable for risk assessment.

Data source

Reference

Reference Type:

publication

Title:

Comparative developmental toxicity of acetylenic alcohols on embryos and larvae of xenopus laevis

Author:

Dawson DA et al.

Year:

1990

Bibliographic source:

Aquatic Toxicology and Risk Assessment 13, , ASTM STP 1096, Landis WG and WH van der Schalie, Eds. American Society for Testing and Materials, Philadelphia, 267-277

Materials and methods

Principles of method if other than guideline:

Method: other

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

But-2-yne-1,4-diol

EC Number:

203-788-6

EC Name:

But-2-yne-1,4-diol

Cas Number:

110-65-6

Molecular formula:

C4H6O2

IUPAC Name:

but-2-yne-1,4-diol

Details on test material:

- Name of test material (as cited in study report):but-2-yne-1,4-diol
- Analytica purity: > 95 %

Test organisms

Test organisms (species):

other: Xenopus laevis, tadpoles

Study design

Study type:

laboratory study

Limit test:

no

Total exposure duration:

96 h

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

15.5 other: mg/l

Basis for effect:

mortality

Any other information on results incl. tables

Comparioson of 12 primary, secondary and tertiary propargylic alcohols and 2 alkene-ols.

 

LC50: 0.18 (0.17-0.23) mmol/L = 15.5 (14.6 – 19.8) mg/L.

The embryo to tadpole toxicity ratio was calculated as 329.2.

 

Since tadpoles have more advanced gill systems in comparison to the embryos, it was discussed, if more toxicant could enter the organisms and reach the site of action. Also the enzyme activity of alcohol dehydrogenase (ADH) was significantly higher in tadpoles (ADH is not present in the embryos before the fourth day of development).

 

Primary and secondary propargylic and homopropargylic alcohols showed an enzyme-mediated reactivity, the tertiary were not reactive. QSAR analysis for non-reactive alcohols indicated that the putative mode of toxic action was narcosis. Excess toxicity (ET) over the baseline toxicity of tertiary alcohols and aleken-ols (putatively narcosis) was calculated for the reactive alcohols in place of QSAR development. For the test substance the excess toxicity was 144000x more toxic than predicted by narcosis. The authors discussed if each –OH group was reactive, greatly increasing the toxicity of this alcohol. Although the test substance had high excess toxicity in the fathead minnow tests, the ET was not nearly as great for Xenopus (Vieth et al. 1989).

 

A comparison of toxicity of all 14 alcohols showed a good correlation between the fathead minnow system and the tadpole lethality endpoint. The authors concluded that the data indicated that toxicity in one system can be used to predict toxicity in the other.