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EC number: 230-949-8 | CAS number: 7381-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between 10 February 2009 and 02 April 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 19/08/08 Date of Signature: 04/03/09
- Type of method:
- flask method
- Water solubility:
- 48.4 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: See 'Remarks'
- Remarks:
- The water solubility of the substance was determined at three different loading rates of 50 g/L, 60 g/L and 100 g/L. Under the conditions of the study, the water solubility of the substance was not dependent on loading rate. A loading level of approximately 100 g/L was considered the highest possible loading at which the test substance is suitable for use. Water solubility values of 46.6 g/L at loading rate of 50 g/L, 51.6 g/L at loading rate of 60 g/L and 47.1 g/L at loading rate of 100 g/L were obtained for the substance. Therefore, an overall water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 48.4 g/L at 20.0 ± 0.5°C.
- Details on results:
- Preliminary test:
The preliminary estimate of water solubility is shown in the following table:
Sample Concentration (g/l)
1 25.0
2 8.22 - Conclusions:
- The water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 46.6 g/l of solution at 20.0 ± 0.5°C when loaded at approximately 50 g/l.
The water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 51.6 g/l of solution at 20.0 ± 0.5°C when loaded at approximately 60 g/l.
The water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 47.1 g/l of solution at 20.0 ± 0.5°C when loaded at approximately 100 g/l.
The overall water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 48.4 g/l at 20.0 ± 0.5°C. - Executive summary:
The water solubility of the test item, Sodium Lauroyl Isethionate, at three different loading rates was determined using the flask method, Method A6 Water Solubility ofCommissionRegulation (EC) No 440/2008 of 30 May 2008.
The loading rates and concentrations are shown in the following table:
Approximate Loading Level (g/l)
Water Solubility at 20.0 ± 0.5°C (g/l)
50
46.6
60
51.6
100
47.1
It was evident from the results obtained that the water solubility was not affected by loading rate. A loading level of approximately 100 g/l was considered to the highest possible loading level concentration. Preparing at greater concentrations would yield a sample which would be unsuitable for use as it would be unfilterable and non-centrifugable. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guideline.
The overall water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 48.4 g/l at 20.0 ± 0.5°C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 July 2013 - 06 September 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with the EC A.6 and OECD 105 guidelines and complied with the principles of GLP.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 1.29 g/L
- Temp.:
- 20 °C
- pH:
- ca. 5.6 - ca. 6
- Remarks on result:
- other: Mean of the analysed concentrations at t=24, 48 and 72 h.
- Details on results:
- The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was 18%. Though the 24 and 72 hour test results were within 15% agreement, it was decided to calculate the water solubility of the test substance as the mean value of all the analysed concentrations because the overall variation was small and each individual result was close to the mean calculated water solubility.
A small peak was detected in the chromatogram of the pretreated sample from the blank water mixture. This response was equal to the response in the analytical blank and was therefore considered not to derive from the water solubility study. - Conclusions:
- The water solubility of the substance at 20°C has been determined as 1.29 g/L using the flask method (GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840). The pH of the saturated solution was 5.6-6.0.
Referenceopen allclose all
Definitive test:
Loading rate 50g/l:
The mean peak areas relating to the standard solutions are shown in the following table:
Solution |
Mean Area |
Standard 10.0 mg/l |
2.103 x 106 |
Standard 50.0 mg/l |
8.717 x 106 |
Standard 100 mg/l |
1.542 x 107 |
Standard 99.8 mg/l |
1.521 x 107 |
Standard 250 mg/l |
3.014 x 107 |
Standard 500 mg/l |
4.885 x 107 |
Matrix blank |
0.000 |
The mean peak areas relating to the sample solutions are shown in the following table:
Solution |
MeanArea |
Sample 1A |
3.112 x 107 |
Sample 1B |
2.963 x 107 |
Sample 2A |
3.158 x 107 |
Sample 2B |
3.175 x 107 |
Sample 3A |
2.783 x 107 |
Sample 3B |
2.792 x 107 |
The calibration curve from which the sample concentrations were interpolated is shown in 1.
The concentration (g/l) of the test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
72 |
24¼ |
47.3 |
7.2 |
2 |
48 |
24¼ |
49.9 |
7.1 |
3 |
24 |
24¼ |
42.5 |
7.2 |
Mean concentration: 46.6 g/l at 20.0 ± 0.5ºC
Range: 42.5 to 49.9 g/l
Loading rate 60g/l:
The mean peak areas relating to the standard solutions are shown in the following table:
Solution |
Mean Area |
Standard 10.0 mg/l |
2.103 x 106 |
Standard 50.0 mg/l |
8.717 x 106 |
Standard 100 mg/l |
1.542 x 107 |
Standard 99.8 mg/l |
1.521 x 107 |
Standard 250 mg/l |
3.014 x 107 |
Standard 500 mg/l |
4.885 x 107 |
Matrix blank |
0.000 |
The mean peak areas relating to the sample solutions are shown in the following table:
Solution |
MeanArea |
Sample 1A |
3.247 x 107 |
Sample 1B |
3.292 x 107 |
Sample 2A |
3.170 x 107 |
Sample 2B |
3.179 x 107 |
Sample 3A |
3.319 x 107 |
Sample 3B |
3.264 x 107 |
The calibration curve from which the sample concentrations were interpolated is shown in Figure 2:
The concentration (g/l) of the test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
72 |
24¼ |
52.1 |
7.1 |
2 |
48 |
24¼ |
50.1 |
7.1 |
3 |
24 |
24¼ |
52.5 |
7.1 |
Mean concentration: 51.6 g/l at 20.0 ± 0.5ºC
Range: 50.1 to 52.5 g/l
Loading rate 100g/l:
The mean peak areas relating to the standard solutions are shown in the following table:
Solution |
MeanArea |
Standard 10.2 mg/l |
2.171 x 106 |
Standard 50.8 mg/l |
9.693 x 106 |
Standard 102 mg/l |
1.773 x 107 |
Standard 109 mg/l |
1.868 x 107 |
Standard 254 mg/l |
3.563 x 107 |
Standard 508 mg/l |
6.018 x 107 |
Matrix blank |
0.000 |
Standard 10.2 mg/l |
2.079 x 106 |
Standard 50.8 mg/l |
9.336 x 106 |
Standard 102 mg/l |
1.704 x 107 |
Standard 109 mg/l |
1.864 x 107 |
Standard 254 mg/l |
3.618 x 107 |
Standard 508 mg/l |
5.952 x 107 |
The mean peak areas relating to the sample solutions are shown in the following table:
Solution |
MeanArea |
Sample 1A |
4.704 x 107 |
Sample 1B |
4.681 x 107 |
Sample 2A |
3.478 x 107 |
Sample 2B |
3.524 x 107 |
Sample 3A |
3.443 x 107 |
Sample 3B |
[1] |
[1]Not enough solution after centrifugation to allow duplicate sampling.
The calibration curve from which the sample concentrations were interpolated is shown in Figure 3 attachment 1.
The concentration (g/l) of the test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
72 |
24 |
69.6[1] |
[2] |
2 |
48 |
24 |
47.6 |
† |
3 |
24 |
24 |
46.6 |
† |
Mean concentration: 47.1 g/l at 20.0 ± 0.5ºC
Range: 46.6 to 47.6 g/l
[1]Not used in calculation of overall mean as inconsistent.
[2]Not enough solution to allow accurate assessment.
Water solubility results
Stirring time [hours] |
Analysed concentration |
Mean [g/l] |
MD [%] |
pH
|
24 |
1.30 |
1.29 |
18 |
5.6 |
48 |
1.17 |
5.9 |
||
72 |
1.40 |
6.0 |
Description of key information
The water solubility of the test item, Sodium Lauroyl Isethionate, has been determined to be 46.6 g/l of solution at 20.0 ± 0.5°C when loaded at approximately 50 g/l. The water solubility of the substance at 20°C has been determined as 1.29 g/L using the flask method (GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840). The pH of the saturated solution was 5.6-6.0.
Key value for chemical safety assessment
- Water solubility:
- 1.29 g/L
- at the temperature of:
- 20 °C
Additional information
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