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EC number: 629-780-6 | CAS number: 1234694-02-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Calculation for main component of Fatty acids, C12-16 and C18-unsaturated, methyl esters
- Justification for type of information:
- see more details on method validity in "Any other information on material and methods".
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 3.016E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 7.28 yr
- Key result
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 266 d
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Calculation for main component of Fatty acids, C12-16 and C18-unsaturated, methyl esters
- Justification for type of information:
- see more details on method validity in "Any other information on material and methods".
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 3.016E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 7.28 yr
- Key result
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 266 d
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model. Calculation for main component of Fatty acids, C12-16 and C18-unsaturated, methyl esters
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 3.016E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 7.28 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 266 d
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
Referenceopen allclose all
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Description of key information
Not relevant due to ready biodegradation
Key value for chemical safety assessment
Additional information
No experimental data evaluating the hydrolysis of Fatty acids, C12-16 (even numbered) and C18 unstd., methyl esters (CAS No. 1234694-02-0) are available. However, according to Regulation (EC) No. 1907/2006, Annex VIII, Column 2, 9.2.2.1, a test on hydrolysis is not required since the substance is readily biodegradable. In addition, the results from the supporting QSAR calculated for the representative fatty acid components (C12, C16 and C18 unstd., HYDROWIN v2.00) indicate that hydrolysis is not a relevant degradation pathway in the environmental fate of this substance. The estimated half-lives (DT50 values) are 7.3 years (pH 7, for all components) and 266 days (pH 8, for all components; López Parrón 2011)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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