Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: other route
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No further information. No details of sex, strains, group sizes or period of administration.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
1994
Reference Type:
publication
Title:
Toxicity of methylolmethacrylamide.
Author:
Novikov SM, Porokhova LA, Kozeeva EE
Year:
1988
Bibliographic source:
Gig. Tr. Prof. Zabol. 9: 55 - 56

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(hydroxymethyl)methacrylamide
EC Number:
213-086-1
EC Name:
N-(hydroxymethyl)methacrylamide
Cas Number:
923-02-4
Molecular formula:
C5H9NO2
IUPAC Name:
N-(hydroxymethyl)-2-methylacrylamide

Test animals

Species:
rat

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Results:
On repeated exposure to N-Methylolmethacrylamide, rats developed ataxia.

Applicant's summary and conclusion