Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The report does not mention whether GLP was followed, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures).
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: vapor from liquid
Details on test material:
- Name of test material (as cited in study report): 1,1 diphenylethane
- Physical state: Clear, colorless liquid
- Lot/batch No.: 31525

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
Supplier- Charles River Breeding Laboratories, Inc., Wilmington, Mass.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
other: No data but whole body exposure was typically conducted.
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures).
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
1.6 and 1.5 mg/L
No. of animals per sex per dose:
4 male rats/exposure
Control animals:
no
Details on study design:
Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures). Observations and body weight were recorded and a gross pathological examination was conducted 2 weeks post-treatment.
Statistics:
None

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.6 mg/L air
Exp. duration:
1 h
Remarks on result:
other: Two 1-hour exposures
Mortality:
None
Clinical signs:
other: Slight, transient eye irritation. At the end of the exposure period the rats were somewhat excitable. However, all rats appeared healthy and gained weight during the 2-week observation period.
Body weight:
All rats appeared healthy and gained weight during the 2-week observation period.
Gross pathology:
No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure.
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Two 1-hour exposures of 4 male rats/exposure to vapor of the test material generated at room temperature resulted in slight, transient eye irritation. There were no mortalities of test animals. No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure.
Executive summary:

Two 1-hour exposures of 4 male rats/exposure to vapor of the 1,1-diphenylethane test material (reference 31525 and a clear, colorless liquid) generated at room temperature (calculated to contain 1.6 and 1.5 mg/l based on weight of samples before and after exposures) resulted in slight, transient eye irritation. At the end of the exposure period the rats were somewhat excitable. However, all rats appeared healthy and gained weight during the 2-week observation period. No lesions attributable to exposure to the test material were observed upon gross pathological examination 2 weeks after exposure. The LC50 for 1,1-diphenylethane was > 1.6 mg/L air.