Registration Dossier
Registration Dossier
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EC number: 202-603-6 | CAS number: 97-72-3
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Hydrolysis
Due to its chemical structure and reactivity, isobutyric anhydride will rapidly hydrolyze in contact with water to isobutyric acid. Thererfore, isobutyric acid data is being used by read across for many of the environmental fate and ecotox endpoints.
Biodegradation
Biodegradation in water: screening test
Isobutyric acid has been shown to be readily biodegradable as combined evidence from two biodegradation tests
1. - test similar to OECD TG 302 B (Hoechst AG, undated; RL2; KS)
2. - test similar to OECD TG 301 E (Henkel KGaA, 1983; RL3; WoE)
Biodegradation in water and sediment: simulation test
In accordance with column 2 of REACH Annex IX Nr. 9.2, the study does not need to be conducted as the substance is readily biodegradable.
Biodegradation in soil
In accordance with column 2 of REACH Annex IX Nr. 9.2, the study does not need to be conducted as the substance is readily biodegradable.
Bioaccumulation
Bioaccumulation: aquatic/sediment
In accordance with column 2 of Annex IX, the study does not need to be conducted if the substance has a low potential for bioaccumulation. The log Kow of 1.1 for isobutyric acid (OXEA, 2009) indicates a low potential for bioaccumulation. Therefore and for reasons of animal welfare a fish study is not performed.
Based on an experimental log Kow of 1.1, the log BCF of isobutyric acid was estimated to be 0.5 (BCF = 3.162). In addition, a log BAF (upper trophic) of 0.31 (BAF = 2.06) was calculated using the method of Arnot-Gobas (ECT, 2010). The low BCF/BAF values indicate a low potential of isobutyric acid for bioaccumulation in aquatic and benthic organisms.
Transport and Distribution
Adsorption/Desorption
In accordance with column 2 of REACH Annex IX Nr. 9.3.3, the study does not need to be conducted as the substance has a low potential for adsorption (log Kow < 3) and is readily biodegradable.
As additional information, the Koc of isobutyric acid was estimated to be 44.7 (log Koc = 1.65; charged molecule) (OXEA, 2010) indicating high mobility in soil.
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