Methyl vinyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to Guideline study with acceptable restriction (report not available for submitter; presumably evaporation of the test substance; clinical signs not recorded daily, 2 animals [but no toxicity reported]; no further details available)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Methyl vinyl ether

EC Number:

203-475-4

EC Name:

Methyl vinyl ether

Cas Number:

107-25-5

Molecular formula:

C3H6O

IUPAC Name:

methoxyethene

Details on test material:

Methyl vinyl ether (MVE), no further information

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

Animals were kept in rooms designed to maintain adequate environmental conditions, and were given a commercial diet and municipal water ad libitum.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

One male and one female New Zealand White Rabbit were subjected to 24 hours of contact with the undiluted, cold test material (not specified further), retained under occlusive dressings on clipped, intact skin of the animals' trunk.

Duration of exposure:

24 h

Doses:

8 ml/kg bw

No. of animals per sex per dose:

1

Control animals:

not required

Details on study design:

The animal was returned to the home cage for the 24 hour contact period. Excess test material was removed after the contact period to diminish ingestion. Observations for skin reactions were made at one hour, 7 days, and 14 days.

Statistics:

not applicable

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 8 mL/kg bw

Remarks on result:

other: ca. 5000 mg/kg bw

Mortality:

no

Clinical signs:

no systemic clinical signs; local effects: light brown sample stain at 1-14 days,erythema and edema at 1st day.

Body weight:

no data

Gross pathology:

no gross lesions

Any other information on results incl. tables

The recommended limit dose according to OECD TG402 is 2000 mg/kg bw.

Applicant's summary and conclusion

Conclusions:

No systemic clinical signs and no mortality were reported after 24 h occlusive exposure to 8 mL/kg bw (ca. 5000 mg/kg bw; cold liquid; recommended limit dose according to OECD402 is 2000 mg/kg bw) in two New Zealand White rabbits; the acute dermal LD50 is > 5000 mg/kg bw.