Registration Dossier
Registration Dossier
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EC number: 219-283-9 | CAS number: 2402-79-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 June 2009 to 10 July 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2,3,5,6-tetrachloropyridine
- EC Number:
- 219-283-9
- EC Name:
- 2,3,5,6-tetrachloropyridine
- Cas Number:
- 2402-79-1
- Molecular formula:
- C5HCl4N
- IUPAC Name:
- 2,3,5,6-tetrachloropyridine
- Details on test material:
- Lot number XF09160201 of purity = 99.4%
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.87
- Temp.:
- 30 °C
- pH:
- 7
Any other information on results incl. tables
The retention times, capacity factors and log10Powvalues determined for the sample are shown in the following table:
Injection |
Retention Time (mins) |
Capacity Factor (k) |
Log10k |
Log10Pow |
1 |
7.424 |
3.68 |
0.566 |
3.87 |
2 |
7.422 |
3.68 |
0.566 |
3.87 |
Mean log10Pow: 3.87
Partition coefficient: 7.43
x 103
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test material has been determined to be 7.43 x 10E3, log10 Pow 3.87.
- Executive summary:
The partition coefficient of the test material has been determined to be 7.43 x 103, log10 Pow 3.87 using theHPLC method, method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008.
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