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EC number: 939-415-5 | CAS number: -
Results table is attached.
OECD guideline 405 and EC Method B.5 (Acute Toxicity: Eye Irritation / Corrosion).
Method and materials
Three New Zealand White male rabbits were exposed to 0.1 mL of test item in the right eye while the left eye remained untreated and served as control. The eyelids were then gently held together for one second before releasing. The eyes were examined and the changes were observed at 1, 24, 48 and 72 h after treatment and graded according to the Draize method.
No corneal or iridial effects were noted during the study. Moderate conjunctival irritation was noted in all treated eyes one hour after treatment with minimal conjunctival irritation noted at the 24 h observation. All treated eyes appeared normal at the 48 h observation. One animal showed body weight loss, one animal showed no gain in body weight and the remaining animal showed expected gain in body weight during the study. Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 0.0, 0.0, 0.0 for cornea score; 0.0, 0.0, 0.0 for iris score; 0.3, 0.3, 0.3 for conjunctivae score and 0.3, 0.3, 0.3 for chemosis score. In this study, the test substance is not an eye irritant in male rabbits.
Under the test conditions, the substance is not classified as irritating to eyes according to CLP Regulation (EC) No. 1272/2008.
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