Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 3,5,5-trimethylhexanoic, n-heptanoic, n-octanoic and n-decanoic acids

Endpoint summary

Description of key information

There is no specific data on the substance. Read-across to the properties of Hexanoic acid, 3,5,5-trimethyl-, 1,1'-[2-ethyl-2-[[(3,5,5-trimethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl] ester (EC 613-848-7, CAS65870-94-2), Fatty acid polyols (Fatty acids, C5-9, esters with pentaerythritol (EC 270-290-3, CAS 68424-30-6) and Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (EC 234-392-1, CAS 11138-60-6)) and their analogues is applicable based on the similarity in structure and physico-chemical properties. Data on structural analogues of the read-across substances are also presented as supporting information and can therefore be used for read-across. The justification for read-across is presented in Section 13 Assessment reports- Read-across justification.

 

Acute fish toxicity: One reliable study is available (Parr, 2014). In this study Rainbow trout (Oncorhynchus mykiss) were exposed to a Water Accommodated Fraction of an analogue substance (EC 613 -848 -7) at a nominal loading rate of 100 mg/L under semi-static conditions for 96 hours. The LL50 (96 h) was > 100 mg/L loading rate WAF. The substance is not acutely harmful to fish.

 

Long-term fish toxicity: One reliable study is available (Parr, 2014). In this study Rainbow trout (Oncorhynchus mykiss) were exposed to a Water Accommodated Fraction of an analogue substance (EC 613 -848 -7) at nominal loading rates of 10, 32 or 100 mg/L under semi-static conditions for 21 days. The LL50 (21 d) was > 100 mg/L loading rate WAF. The No Observed Effect Loading Rate was 100 mg/L loading rate WAF. The substance is not harmful to fish after prolonged exposure.

 

Acute toxicity to aquatic invertebrates: One reliable study is available (Harris, 2013). In this study Daphnia magna were exposed to a Water Accommodated Fraction of an analogue substance (EC 613 -848 -7) at a nominal loading rate of 100 mg/L under static conditions for 48 hours. The EL50 (48 h) value was > 100 mg/L loading rate WAF. The substance is not acutely harmful to aquatic invertebrates.

 

Long-term toxicity to aquatic invertebrates: One reliable study is available (Harris, 2014). In this study Daphnia magna were exposed to a Water Accommodated Fraction of an analogue substance (EC 613 -848 -7) at nominal loading rate of 1.0, 3.2, 10, 32 or 100 mg/L under semi-static conditions for 21 days. The EL50 (21 d, immobilization) value was > 100 mg/L loading rate WAF. The EL50 (21 d, reproduction) value was > 100 mg/L loading rate WAF. The Lowest Observed Effect Loading Rate was 32 mg/L loading rate WAF (based on production of live young per adult) and the No Observed Effect Loading Rate was 10 mg/L loading rate WAF (based on parental mortality and production of live young per adult).

 

Toxicity to algae: One reliable study is available (Vreyenhoef, 2014). In this study Pseudokirchneriella subcapitata were exposed to a Water Accommodated Fraction of an analogue substance (EC 613 -848 -7) at a nominal loading rate of 100 mg/L under static conditions for 72 hours. The ErL50 (72 h) value was > 100 mg/L loading rate WAF. The NOELR was 100 mg/L loading rate WAF. The substance is not harmful to algae.

 

Toxicity to micro-organisms: One reliable study is available (Roulstone, 2013). In this study activated sewage sludge was exposed to aqueous dispersions of an analogue substance (EC 613 -848 -7) at up to 1000 mg/L with the addition of synthetic sewage as a respiratory substrate for 3 hours. Based on the rate of respiration, the EC50 (3 h) was > 1000 mg/L and the NOEC (3 h) was 1000 mg/L. The substance is not harmful to microorganisms.

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