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Biodegradation in water: screening tests

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Description of key information

The analogue substance is readily biodegradable according to OECD criteria.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

There is no specific data on the substance. Read-across to the properties of Hexanoic acid, 3,5,5-trimethyl-, 1,1'-[2-ethyl-2-[[(3,5,5-trimethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl] ester (EC 613-848-7, CAS65870-94-2),Fatty acid polyols (Fatty acids, C5-9, esters with pentaerythritol (EC 270-290-3, CAS 68424-30-6) and Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (EC 234-392-1, CAS 11138-60-6)) and their analogues is applicable based on the similarity in structure and physico-chemical properties.

The justification for read-across is presented in Section 13 Assessment reports- Read-across justification.

In the key study performed to OECD Guideline 301B, EC Method C.4 -C and US EPA OPPTS 835.3110 EC 613 -848 -7 at a concentration of 10 mg C/L was exposed to activated sewage sludge micro-organisms with a mineral medium in sealed culture vessels in the dark at 21 to 23°C for 28 days. The degradation of the test item was assessed by the determination of carbon dioxide produced.

The test item attained 104% degradation after 28 days and satisfied the 10-day window validation criterion. The test item can therefore be considered to be readily biodegradable.

Two studies, investigating the ready biodegradability of Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (

EC 234-392-1, CAS-No 11138-60-6) according to OECD 301B (CO2 Evolution Test), are available. In both studies domestic activated sludge (non adapted) was used as inoculum. In the key study (Häner, 2007) a mean degradation of 72% after 28 days could be observed and in the supporting study (Muckle, 2008) the test substance was degraded to 78.9% after 29 days. In both studies the 10-day-window was reached. The test substance can be classified as readily biodegradable according to OECD criteria.

A supporting study investigating the ready biodegradability of Fatty acids, C5-9 esters with pentaerythritol (EC 270 -290 -3, CAS-No. 68424-30-6) according to OECD 301B (CO2 Evolution), is available. In this study (Defleur, 1999) the biodegradation was tested in a CO2 Evolution test according to OECD 301B using domestic activated sludge as inoculum. At test termination after 28 days the substance had degraded 63.1%, but did not fulfil the 10 -day-window criteria. As the test substance is a mixture of constituents with different chain-lengths, sequential biodegradation of the individual structures is taking place. Due to a degradation of > 60% within 28 days Fatty acids, C5-9 esters with pentaerythritol (CAS-No. 68424-30-6) can be regarded as readily biodegradable. The 10 -day window validity criteria for ready biodegradation should not be applied to this substance (Annex I, OECD Guideline for The Testing of Chemicals 'Revised introduction to the OECD guidelines for testing of chemicals, section 3', OECD, March 2006).