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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Remarks:
Similar to, but not conducted under current guideline skin corrosion test methodology.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Skin Corrosion Test as defined in Department of Transportation Hazardous Materials Regulations, Title 49 CFR, Section 173.240(a)(1), December 31, 1973.
Deviations:
no
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Terephthaloyl dichloride
EC Number:
202-829-5
EC Name:
Terephthaloyl dichloride
Cas Number:
100-20-9
Molecular formula:
C8H4Cl2O2
IUPAC Name:
terephthaloyl dichloride
Constituent 2
Reference substance name:
Terephthaloyl chloride
IUPAC Name:
Terephthaloyl chloride
Details on test material:
- Purity: 99.9%
- Impurities: Not reported

Test animals

Species:
rabbit
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Albino rabbits
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2-3 kg
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
Duration of treatment / exposure:
4 hours
Observation period:
Observations done at 4, 24 and 48 hours.
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: Back
- % coverage: 1.5 by 1.5 inch coverage
- Type of wrap if used: 12 ply cotton gauze pads then trunk of animal loosely wrapped with rubber sheeting.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 4 hours

SCORING SYSTEM: Not reported

Skin reactions were evaluated after removal of the wrapping. Readings were again made at 24 and 48 hours after the initial application.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: corrosion
Basis:
animal: 1 - 5
Time point:
other: 4, 24, 48 hours
Remarks on result:
other: no skin corrosion
Irritation parameter:
erythema score
Basis:
animal: 1-5
Time point:
24 h
Remarks on result:
other: no skin corrosion
Irritation parameter:
erythema score
Basis:
animal: 1-5
Time point:
48 h
Remarks on result:
other: no skin corrosion
Irritation parameter:
erythema score
Basis:
animal: 1-5
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
animal: 1-5
Time point:
24 h
Remarks on result:
other: no skin corrosion
Irritation parameter:
edema score
Basis:
animal: 1-5
Time point:
48 h
Remarks on result:
other: no skin corrosion
Irritation parameter:
edema score
Basis:
animal: 1-5
Time point:
72 h
Remarks on result:
not measured/tested
Irritant / corrosive response data:
No skin corrosion in any of the rabbits.
Other effects:
One rabbit died prior to 24-hour reading from non-compound related cause.

Any other information on results incl. tables

Hours after Initial Application

Number of Rabbits with Skin Corrosion

4

0/6

24

0/5

48

0/5

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Not corrosive to skin.
Executive summary:

0.5 gm of the test substance was applied to a 1.5 by 1.5 inch area of the clipped dorsal skin of six albino rabbits. The treated area was covered with an occlusive dressing. After 4 hours, the wrapping was removed any skin reactions evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours after the initial application. There was no skin corrosion. One rabbit died prior to the 24-hour reading from non-compound related cause. According to the Regulations of the Department of Transportation, the test substance is not corrosive to skin.