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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Remarks:
One animal per group.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Principles of method if other than guideline:
The test substance, as a suspension in corn oil, was administered by gavage to young adult male rats in a single dose (1 rat/dose level). Dose levels were 670, 1500, 2500, 3400, 5000, 7500 mg/kg. Survivors were sacrificed 14 days later. Animals were observed for toxic signs, body weight changes, mortality and moribunditity.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Terephthaloyl dichloride
EC Number:
202-829-5
EC Name:
Terephthaloyl dichloride
Cas Number:
100-20-9
Molecular formula:
C8H4Cl2O2
IUPAC Name:
terephthaloyl dichloride
Constituent 2
Reference substance name:
Terephthaloyl chloride
IUPAC Name:
Terephthaloyl chloride
Details on test material:
- Purity: 99.9%

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: Young adult

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
10% suspension for concentrations of 670-2250 mg/kg.
20% suspension for concentrations of 3400-7500 mg/kg.
Doses:
670, 1500, 2250, 3400, 5000, 7500 mg/kg. The highest dose was administered in divided dose.
No. of animals per sex per dose:
1 rat/dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration was 14 days.
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: Not reported
- Other examinations performed: Clinical signs and body weight.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: approximate lethal dose (ALD)
Effect level:
5 000 mg/kg bw
Mortality:
At 7500 mg/kg death at day one.
At 5000 mg/kg death at day six.
Clinical signs:
Lethal doses: Discomfort and inactivity after dosing. Irregular respiration on day of dosing. Heavy breathing, weakness, blood in urine, absence of faeces for 2 days.
Non-lethal doses: Discomfort and inactivity after dosing. Irregular respiration on day of dosing, blood-stained mouth, and mild diarrhoea for 1 day.
Body weight:
Lethal doses: Continuous weight loss at 5000 mg/kg.
Non-lethal doses: Weight loss for 2 days at 3400 mg/kg. Initial weight loss at 1500 and 2250 mg/kg.
Gross pathology:
Not reported.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
ALD = 5000 mg/kg
Executive summary:

The test substance, as a suspension in corn oil, was administered by gavage to young adult male rats in a single dose (1 rat/dose level). Dose levels were 670, 1500, 2500, 3400, 5000, 7500 mg/kg. Survivors were sacrificed 14 days later. Animals were observed for toxic signs, body weight changes, mortality and moribunditity. The ALD was 5000 mg/kg.