Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: no glp, only similar to guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- GLP compliance:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 4 and 13 weeks
- Frequency of treatment:
- daily with diet
- Remarks:
- Doses / Concentrations:
0.00, 0.03, 0.10, 0.30, 1.00 % Sn in diet
Basis:
nominal in diet - No. of animals per sex per dose:
- 10 animals per sex per dose per timeframe.
- Control animals:
- yes
- Dose descriptor:
- NOEL
- Effect level:
- > 22 - < 33 other: mg Sn /kg bw day
- Based on:
- element
- Sex:
- male/female
- Critical effects observed:
- not specified
- Conclusions:
- Severe growth retardation,
decreased food efficiency, slight anaemia and slight histological changes in the liver were
observed with 0.3 70 or more of stannous sulphate.
As NOAL a value of 22-33 mg Sn/kg bw day was determined, no LOAEL was fouind.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 39 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
repeated toxicty dermal and irritation not performent, resaon see acute toxicity
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: other
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
