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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In accordance with column 2 of REACH annex VIII, it is considered justifiable to omit the acute toxicity studies as the substance is classified as corrosive to the skin.
The following supporting studies were available for the acute toxicity: oral endpoint:
Schafer E. W. & Bowles A. W. (1985). Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice. Arch. Environ. Contam. Toxicol. 14: 111-129. Testing laboratory: U. S. Department of Interior - Fish and Wildlife Service, Denver Wildlife Research Center, Building 16 - Denver Federal Center, Denver, Colorado 80225.
Result: An approximate lethal dose of dibutyltin diacetate in deer mice was determined to be 1070 mg/kg. A second toxicity test determined the LD50 of dibutyltin diacetate of >87.5 mg/kg/day.
Acros Organics (2007). Material Safety Data Sheet. Dibutyltin diacetate pract. website https: //fscimage. fishersci. com/msds/75959. htm. Owner company: Acros Organics N. V., One Reagent Lane, Fair Lawn, NJ 07410. Study number: ACC# 75959. Report date: 2007-03-16.
Result: This MSDS reported an LD50 of 46mg/kg for dibutyltin diacetate for mouse and an LD50 of 32mg/kg for rat. According to the MSDS, dibutyltin diacetate is classified as 'Toxic if Swallowed'.

Key value for chemical safety assessment

Additional information

Although data were available concerning acute toxicity via the oral route, the data is not adequate to accurately assign a classification. The material safety data sheet from Arcos Organics (2007) as a secondary source cannot be assessed for reliability, further to this, the safety data sheet does not reference the data sources. The available literature study, Schafer & Bowles (1985), although performed in line with good scientific principles, the study is not performed in the preferred species, and the data available is not sufficient to assess the acute toxicity of dibutyltin di(acetate).

Justification for classification or non-classification

From the data available, it is not possible to accurately assign a classification. From the results of the presented in vitro skin corrosion study (Warren, 2010), dibutyltin di(acetate) is considered corrosive, and any further testing is waived on ethical grounds.