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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The following data have been submitted to address the short-term toxicity to fish endpoint:
Steger-Hartmann T and Wendt B (1998). Acute toxicity of di-n-butyltin oxide (ZK 26385) to the Zebra fish, Danio rerio. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342, Berlin Germany. Report no.: IC19. Owner company: Schering AG, Experimentelle Toxikologie, Berlin Germany. Study number: TXST19980196. Report date: 1998-12-11.
The key value for the chemical safety assessment is a LOEC (72h) of 3.1 mg/l taken from the Steger-Hartmann and Wendt (1998) study performed dibutyltin oxide.
Nagase H, Hamasaki T, Sato T, Kito H, Yoshioka Y & Ose Y (1991). Structure-activity relationships for organotin compounds on the red killifish Oryzias latipes. Applied Organometallic Chemistry 5:91-97.
Result: The 48 hr LC50 for di-n-butyltin diacetate was determined to be 1.07 x 10-2 mmol dm-3 in the red killifish under semi-static conditions.
Nagase, H., Hamasaki, T., Sato, T., Kito, H., Yoshioka, Y. and Ose, Y. (1991). Structure - activity relationships for organotin compounds on the red killifish 'Oryzlas latipes'. Applied Organometallic Chemistry 5: 91-97.
Result for DBTO: The short term LC50 is 0.839 mg/L.
The key study for this endpoint, Steger-Hartmann & Wendt (1998) was performed on dibutyltin oxide as the data available on dibutyltin diacetate is not sufficient for assessment.

Key value for chemical safety assessment

Additional information

Read-across between dibutyltin compounds to to dibutyl diacetate concerning aquatic toxicity endpoints was considered appropriate as dibutyltin and octyltins are known to hydrolyse rapidly in water (as presented by Yoder 2003, under the data requirement hydrolysis), and form, in the case of dibutyltins, dibutyltin oxide.

The key study, Steger-Hartmann and Wendt (1998) has been allocated a Klimisch score of 2, as it was used as read across from a supporting substance. The study was performed to the guideline OECD 203. Only one fish died during the course of the 72 hour study, when tested up to the saturation point. Only a 72 hour LOEC of 3.1 mg/L could be determined from the study.

The Nagase et al (1991) study (the data were sourced from the same publication but reported as two separate endpoints, results from tests with dibutyltin di(acetate) and dibutyltin oxide respectively) have been allocated a Klimisch score of 4 due to a lack of detail in the reporting of the methods and results. Only 48 hours LC50's were reported. These studies are considered to be supporting studies.The 48 hr LC50 for di-n-butyltin diacetate was determined to be 1.07 x 10 -2 mmol dm-3 in the red killifish under semi-static conditions. For DBTO, the short term LC50 was 0.839 mg/L.